top of page
  • Writer's picturePinnacle Global Travel

10 Nights Ohio River Cruise | Pittsburgh to Saint Louis, and reverse (Call For Pricing)

Updated: Dec 10, 2022

Cruise Ship

United States | American Cruise Lines - Queen of the Mississippi

Departure Dates:

June - September, ask for details.

Ports of Call:

Pittsburgh, Pennsylvania; Marietta, Ohio; Maysville, Kentucky; Cincinnati, Ohio; Louisville, Kentucky; Henderson, Kentucky; Paducah, Kentucky; Cape Girardeau, Missouri; Saint Louis, Missouri

General Info:

Experience two of America's greatest rivers on this 11-day adventure through the heartland. Enjoy the idyllic countryside of the Ohio River and the wonder of the mighty Mississippi that inspired Mark Twain. The Ohio River was pivotal in the development and exploration of the American West and along the way, the team will highlight much that has defined our American roots from the Civil War to bluegrass music. Or, you can take a milder pace and just kick back with a rocking chair and a glass of sweet tea on the sun deck while American Cruise Lines handles the rest. Each port of call showcases a new element of Americana. In Henderson, for instance, you may visit the John James Audubon Museum, which features many original works and join the expert guide to learn about the sense of natural wonder that Audubon instilled in so many Americans. While in Louisville, you are treated to a behind the scenes journey of the Churchill Downs, the site of the famed Kentucky Derby, and sample the finest bourbon at the famous Jim Beam Distillery, each destination with a distinct American story to tell. Every cruise on the Ohio River is unique due to fluctuating river conditions that can have an impact on the itinerary. The river has a mind of its own and, as it has been since the dawn of river travel, the sailing schedules must adapt to it. It is possible that guests will be transported between a town on the Ohio River and Pittsburgh by coach for excursions or embarkation.


Built in 2015, Queen of the Mississippi offers an authentic paddle wheeler experience with all the comforts of home. Guests can enjoy large staterooms with private balconies, hotel-style bathrooms, and complimentary room service. Experience breathtaking scenery from the privacy of your stateroom as the Queen of the Mississippi makes its way down the legendary river.


Day 1 | Pittsburgh, Pennsylvania: Begin your journey in "steel city," Pittsburgh. Long known for steel manufacturing, Pittsburgh was an essential stop along the Ohio River for national and international commerce, making it a wealthy town in the 18th and 19th centuries. Named after Republican Politician Senator John Heinz, this interactive museum is full of six floors worth of Western Pennsylvania History, covering the past 250 years. Exhibits include the life of Senator John Heinz, the history of Pittsburgh, professional sports memorabilia, and much more. This excursion is only available on cruises ending in Pittsburgh. Day 2 | Marietta, Ohio: The second-largest city in the Parkersburg-Marietta-Vienna Metropolitan area, Marietta was named in honor of Marie Antoinette. During the 18th and 19th century, the town experienced economic prosperity, as its location on the Ohio River made it an attractive stop for commercial steamboats, as well as travelers. Explore two of Marietta's greatest treasures: the Campus Martius Museum and the Ohio River Museum. The Campus Martius Museum features exhibits focusing on America's migration out West and Marietta's earliest native inhabitants. At the Ohio River Museum, discover the golden age of the steamboat and learn about the ecology of the Ohio River system. Visit this beautifully preserved, 1855 Gothic-Revival house, The Castle Historic House Museum, which is on the National Register of Historic Places. The Castle was once home to some of Marietta's most prominent citizens and the site of many prestigious functions. Hear fascinating stories about its history and learn about of one of the oldest regions in the Northwest Territory. Day 3 | Maysville, Kentucky: Maysville is a quaint town with a rich history. An important stop on the Underground Railroad, Maysville was host to Harriet Beecher Stowe in 1883. Your stop will include idyllic country scenery and the native sounds of original Bluegrass Country music. Step back in time while you view the historic town of Old Washington. Starting at the 1790s Visitor Center, your costumed guide will lead you through this historic Kentucky village, taking you along flagstone sidewalks graced with authentic frontier log cabins and early 19th-century homes. This two-hour walking exploration will include stops at the Simon Kenton Shrine, Albert Sidney Johnston House, and the Harriett Beecher Stowe Slavery to Freedom Museum. Enjoy the small town charm of historic Maysville, during this narrated journey. Begin at the Kentucky Gateway Museum Center, which brings the stories of explorers, artists, and movie stars to life through award-winning dioramas and its collection of historic artifacts. Next, visit the historic Russell Theater, a true piece of the town's history. The excursion will conclude at the Cox Building which was built in 1886 and features Richardson Romanesque architecture. Day 4 | Cincinnati, Ohio: Enjoy a visit to Cincinnati, a vibrant city and cultural center which boasts two major sports franchises, a zoo and botanical garden, and numerous theaters and museums. Stroll along its picturesque streets, abounding in eclectic architecture and shop at the famous Findlay Market, a longtime gathering place for vendors to sell local goods, meats, and fresh produce. Explore both sides of the river on this fantastic, all-encompassing excursion. Highlights include the floodwall murals, downtown river district, Saint Mary's Cathedral Basilica of the Assumption, and Eden Park. Built in 1933, Krohn Conservatory lies in the heart of Eden Park. This art deco building is architecturally significant, but it is the contents inside the aluminum and glass walls that make it truly special. The Conservatory is home to more than 5,000 varieties of exotic, tropical, desert, and orchid plants from around the world. The National Underground Railroad Freedom Center celebrates the brave men and women who came together to create a secret network through which the enslaved could escape to freedom. Their example of courage, cooperation, and perseverance is relevant to this day, as we continue to deal with contemporary issues of equality and diversity. Day 5 | Louisville, Kentucky: Named after King Louis XVI of France, Kentucky was originally a part of Virginia, becoming the 15th state to join the Union in 1792. Louisville is best known for the famed Kentucky Derby, the first leg of the Triple Crown of Thoroughbred Racing, and the oldest continuously held horse race in the country. Discover why Louisville is often referred to as either the northernmost southern city or the southernmost northern city in the United States. Louisville Slugger is the maker of the world's most popular bat. The company's storied traditions and high standards for quality have produced some of the finest bats for amateurs and professionals alike. Take a guided exploration of the facility and museum, learning first-hand their processes from forest-to-factory and the scientific principles used to fabricate the most important tool in "America's Game." Enjoy special seasonal exhibits and receive a free souvenir bat to commemorate your visit. Bourbon enthusiasts will revel in a visit to the famous Jim Beam distillery. Celebrate "America's First Family of Bourbon," as you learn about their over 200 years of bourbon-making and view historic artifacts. Your private excursion will include a visit to the home where three generations of Beam distillers lived. Step inside the Stillhouse Exhibit, which features an authentic 1800s copper, believed to be one of the oldest in America. Your excursion will conclude in the rack house, where the bourbon is aged and the sampling begins. Visit the popular gift shop to purchase a variety of bourbons, bar ware, and other Jim Beam merchandise. Day 6 | Louisville, Kentucky: Spend another day in Kentucky, known as the "Bluegrass State," due to the bluegrass found in many of its pastures because of the fertile soil. Admire the city's architecture which is a blend of old and new. Explore the Old Louisville neighborhood, the largest historic preservation district in the United States, solely featuring Victorian homes and buildings. Get a behind-the-scenes view of the Churchill Downs, the site of the famed Kentucky Derby. Here, you will have exclusive access to every facet of the race, from the Press Box and Jockey's to Millionaire's Row, the most coveted seats on race day. Visit the Kentucky Derby Museum to see actual Derby footage dating as far back as 1918. Day 7 | Henderson, Kentucky: You won't miss the presence of the notable resident, John James Audubon, whose "Birds of America" paintings are recreated as bronze statues throughout Henderson. Named after President Washington's home on the Potomac, this bucolic river town is steeped in fascinating lore. Let your expert guide lead you on a journey of the famous first President's historic home and grounds. After docking in the tranquil port of Henderson, your morning will begin with a short narrated walk to the famous John James Audubon Museum. Listed in the National Register of Historic Places, the museum features many original oil and watercolor paintings created by Audubon as well as many of his personal possessions. Your day will continue with the resident naturalist who will provide a narrated excursion of the popular Nature Center, which was recently named one of the Top 25 Bird Watching Spots. At the conclusion of the visit, you will have free time for independent exploration. Day 8 | Paducah, Kentucky: Residing at the confluence of the Tennessee River and the Ohio River, Paducah will make you feel as if you stepped back in time. As you walk the streets of this Chickasaw village site, discover Paducah's rich history. View the Wall-to-Wall Mural Program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War, and area landmarks such as the Old Carnegie Library. Let the local guide take you through the quaint city of Paducah. This experience has been carefully divided into three distinct sections to make sure you experience all that Paducah has to offer. First, visit the downtown as your local expert guide points out the areas' many historical sites. Then, take a leisurely stroll along the riverfront where you will witness more than 50 life-sized panoramic murals depicting elements of Paducah's past. End the experience at the National Quilt Museum, the world's largest museum devoted to quilt and fiber art. Just a short distance from the ship's docking location is the River Discovery Center, where guests learn about the Four Rivers region. Explore state-of-the-art interactive exhibits such as the working lock and dam model and the pilothouse simulator which allows you test your skills and captain your own riverboat! Day 9 | Cape Girardeau, Missouri: Enjoy the charming features of this historic town that in the late 1800s was a French trading post and lively river port. Today, it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Cape River Heritage Museum and the Red House Interpretive Center. The evening before arriving in Cape Girardeau, your onboard historian will paint a vivid picture of the Cherokee peoples' crossing of the Mississippi River to land in present-day Oklahoma. The forced march became known by the Cherokee people as the Trail of Tears due to its devastating effects. Led by the expert guide, explore the interpretive center, which houses a series of panels, paintings, maps, and other memorabilia depicting the Cherokees' tragic crossing of the Mississippi River. Join a local guide on a narrated journey of Cape Girardeau and stop at the Crisp Museum. A part of the River Campus of Southeast Missouri State University, the museum features fine art exhibitions, prehistoric Native American artifacts, one of the largest collections of ceramic conch shell effigies in North America, and interpretive regional history displays. Upon arrival, watch a wonderful introductory film, followed by a museum excursion, where you can view a life-sized replica of a Native American dwelling. Day 10 | Saint Louis, Missouri: Saint Louis is sure to win you over. Admire the scenic riverfront, highlighted by the majestic Gateway Arch, the largest man-made monument in the United States Enjoy Saint Louis' many world-class attractions, including the Art Museum, Science Center, and the Missouri History Museum. End your day at the Missouri Botanical Garden, one of the world's most popular public gardens. Enjoy a guided excursion through two of the museum's most popular exhibits; The 1904 World's Fair: Looking Back at Looking Forward, an event that attracted over 200,000 visitors to the opening day, and Seeking Saint Louis, delve into the history of the Gateway City from its founding through the new millennium. Enjoy a narrated journey of downtown Saint Louis, the riverfront, Citygarden, and the historic neighborhoods of Soulard and Lafayette Square. Delight in a visit to Saint Louis' 1,371-acre Forest Park, known as a natural oasis in an urban environment. Stop at the Cathedral Basilica, where you explore the interior if this stunning church which rivals the cathedrals in Rome, Italy. This excursion is only offered on cruises ending in Saint Louis. Day 11 | Saint Louis, Missouri: Departure day. We recommend you spend an extra day to explore this vibrant city. Visit the Missouri Botanical Garden, one of the world's most popular public gardens.


The all-American crew from American Cruise Lines simply provides you with the best possible cruise experience by offering an unsurpassed level of attention. Whether onboard or ashore, each member of the crew will work with you to help accommodate your specific interests, tastes, and needs. Attentive and personalized service is the hallmark of American Cruise Lines.


Meals are served in the spacious dining salon, which accommodates all passengers at one seating. The day's menu is announced well in advance, and consists of fresh meats and seafood, as well as in-season fruits and vegetables. Special menus are available to passengers on restricted diets. Most special dietary needs can be accommodated, though advance notice. All meals are prepared to order. Coffee, non-alcoholic beverages, and snacks are available 24 hours a day.


Let American Cruise Lines guide you through the origins and rich traditions of music on America's legendary rivers and waterways. These shores are home to many celebrated styles of music including Country, Jazz, Blues, and Rock n' Roll. Onboard and ashore, enjoy music inspired by each unique region and learn its impact on the development of American music. Also enjoy daily entertainments from historians, naturalists, and local experts that join every cruise. Daily lectures ranging from history to culture to cuisines.


On this eight day journey from Saint Louis to Pittsburg, explore the America of yesteryear. The art, music, history, and natural beauty of the region is an all-encompassing experience. Shore Excursions include the Kentucky Derby Museum and Horse Park, Audubon Museum Experience, Jim Beam American Outpost and the National Underground Railroad Freedom Center.


Owner's Suites | At a generous up to 445 square feet, these suites offer the finest accommodations with unsurpassed views of the Mississippi River. With a spacious seating area and full-size bathrooms, each suite is a private sanctuary where you can unwind after a day of exploration in the tasteful comfort of your surroundings. Each of these suites features large sliding glass doors leading out to a private balcony, where you can enjoy the ever-changing scenery. Every modern amenity is at your fingertips, along with a desk, and spacious seating area. AAM Staterooms | Located on the top deck, these spacious staterooms feature scenic views of the passing landscape. At 328 square feet, you will enjoy all of the modern comforts that are expected of a premium hotel. These staterooms also offer full-size bathrooms and a walk-out private balcony where the grandness of the Mississippi can be appreciated. AAC Staterooms | Conveniently located on the fourth deck and at 304 square feet offer all of the comforts of a fine hotel. Complete with a private balcony and floor-to-ceiling sliding glass doors, these staterooms provide spectacular panoramic views of the Mississippi River and the surrounding landscape. AAL Staterooms and AAR Staterooms | Enjoy a luxurious 304 square feet of living space that is equipped with plush seating, a full-size bathroom, and a private balcony with large sliding glass doors that offer great views of the Mississippi scenery. A Staterooms | These 290 square feet staterooms offer exceptional comfort and a relaxing living area. Featuring a large opening picture window, all are equipped with modern amenities, full-size bathrooms, and closet space. Single (Private Balcony) Staterooms | Perfect for the solo traveler, offering all of the amenities you expect from a fine hotel. At 230 square feet, these staterooms have spacious bathrooms and large sliding glass doors that lead to a private balcony. Single Staterooms | A comfortable getaway, offering individuals a spacious room with convenient amenities. At 203 square feet, all have interior entrances and large viewing windows where the sights of the Mississippi can be enjoyed.


bottom of page